CENTER FOR CHEMICAL BIOLOGY AND BIOTECHNOLOGY (C2B2) AT UNIVERSITY OF SAN AGUSTIN
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Below is a complete list of peer-reviewed publications in collaboration with scientists, postdoctoral scholars, graduate, and undergraduate students in the field of natural products chemistry and microbiology.
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ORCID Account
Scholarly Presentations

46. Balida, L.A.P.; Regalado, J.T.A.; Teodosio, J.J.R.; Dizon, K.A.H.; Sun, Z.; Zhan, Z.Q.; Blancaflor, J.M.D.; Sollesta, J.V.N.; Villorente, Z.M.; Saludes, J.P.; Dalisay, D.S. Antibiotic Isoflavonoids, Anthraquinones, and Pterocarpanoids from Pigeon Pea (Cajanus cajan L.) Seeds against Multidrug-Resistant Staphylococcus aureus. Metabolites 2022, 12, 279. https://doi.org/10.3390/metabo12040279
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45. ​Dumancas, G.G.; Setijadi, C.; Dufour, B.; Aglobo, J.;  Carisma, M.S.; Bello, G. A.;  Dalisay, D.S.; Saludes, J.P.  “Comparison of Genetic and Non-genetic Algorithm Partial Least Squares for Sugar Quantification in Philippine Honeys”, Analytical Letters, 2022, 
doi.org/10.1080/00032719.2022.2033985
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44. ​Villanueva, N. S. P.; Vicera, C. V. B.; Leonida, S. F. L.; Paderog, M. J.; Sabido, E. M.; Saludes, J. P; Dalisay, D. S.  “Barringtonia asiatica Seed Extract Induces G1 Cell Cycle Arrest in Saccharomyces cerevisiae and Exhibits Cytotoxicity in A2780 Human Ovarian Cancer Cells”, Journal of Pharmaceutical Research International, 2021, 33(53A), 372-387.
doi: 10.9734/jpri/2021/v33i53A33672.
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43. Makarieva, T.N.; Ivanchina, N.V.; Dmitrenok, P.S.; Guzii, A.G.; Stonik, V.A.; Dalisay, D.S.; Molinski, T.F. Oceanalin B, a Hybrid α,ω-Bifunctionalized Sphingoid Tetrahydroisoquinoline β-Glycoside from the Marine Sponge Oceanapia sp. Marine Drugs 2021, 19, 635.  https://doi.org/10.3390/md19110635
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42. Tenebro, C.P.; Trono, D.J.V.L.; Vicera, C.V.B.; Sabido, E.M.; Ysulat, J.A.Y.; Macaspac, A.J.M.; Tampus, K.A.; Fabrigar, T.A.P.; Saludes, J.P.S.; Dalisay, D.S.  Multiple strain analysis of Streptomyces species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities. Scientific Reports 2021, 11, 17544. https://doi.org/10.1038/s41598-021-96886-4
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41. Sabido, E.M.; Tenebro, C.P.; Trono, D.J.V.L.; Vicera, C.V.B.; Leonida, S.F.L.; Maybay, J.J.W.B.; Reyes-Salarda, R.; Amago, D.S.; Aguadera, A.M.V.; Octaviano, M.C.; Saludes, J.P.; Dalisay, D.S. Insights into the Variation in Bioactivities of Closely Related Streptomyces Strains from Marine Sediments of the Visayan Sea against ESKAPE and Ovarian Cancer. 
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Marine Drugs 2021, 19, 441.  https://doi.org/10.3390/md19080441
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40. Suarez, A.F.L.; Tirador, A.D.G.; Villorente, Z.M.; Bagarinao, C.F.; Sollesta, J.V.N.; Dumancas, G.G.; Sun, Z.; Zhan, Z.Q.; Saludes, J.P.; Dalisay, D.S. The Isorhamnetin-Containing Fraction of Philippine Honey Produced by the Stingless Bee Tetragonula biroi Is an Antibiotic against Multidrug-Resistant Staphylococcus aureus. Molecules 2021, 26, 1688. https://doi.org/10.3390/molecules26061688
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39. Dalisay,D.S., Rogers,E.W., Molinski, T.F. Oceanapiside, a Marine Natural Product, Targets the Sphingolipid Pathway of Fluconazole-Resistant Candida glabrata. Marine Drugs 2021, 19, 126. https://doi.org/10.3390/md19030126
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38. Sabido, E.M.; Tenebro, C.P.; Suarez, A.F.L.;  Ong, S.D.C.; Trono, D.J.V.L.; Amago, D.S.; Evangelista J.E. Jr.; Reynoso, A.M.Q.; Villalobos, I.G.M.;  Alit, L.D.D.;  Surigao, C.F.;  Villanueva, C.A.; Saludes, J.P.; Dalisay, D.S.  Marine Sediment-Derived Streptomyces Strain Produces Angucycline Antibiotics against Multidrug-Resistant Staphylococcus aureus Harboring SCCmec Type 1 Gene. Journal in Marine Science and  Engineering. 2020, 8 (10), 734; https://doi.org/10.3390/jmse8100734
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37. Paderog, M.J.V.; Suarez, A.F.L.; Sabido, E.M.; Low, Z.J.; Saludes, J.P.; Dalisay, D.S. Anthracycline Shunt Metabolites From Philippine Marine Sediment-Derived Streptomyces Destroy Cell Membrane Integrity of Multidrug-Resistant Staphylococcus aureus. Frontiers in Microbiology 2020, 11, 743. DOI:10.3389/fmicb.2020.00743
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36. Williams, D.E., Dalisay, D.S., Chen, J., Polishchuk, E.A., Patrick, B.O., Narula, G., Ko, M., Av-Gay, Y., Li, H., Magarvey, N., Andersen, R.J.  “Aminorifamycins and sporalactams produced in culture by a Micromonospora sp. isolated from a Northeastern-Pacific marine sediment are potent antibiotics”. Organic Letters. 2017, 19, (4), 766–769 DOI:10.1021/acs.orglett.6b03619
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35. Jamison, M.; Dalisay, D.S.; Molinski, T. F.  "Peroxide Natural Products from Plakortis zyggompha and the Sponge Association Plakortis halichondrioides-Xestospongia deweerdtae. Antifungal Activity Against Cryptococcus gattii". Journal of Natural Products. 2016, 79 (3), 555–563. DOI: 10.1021/acs.jnatprod.5b00951
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34. Williams, D.; Izard, F.; Arnould, S.; Dalisay, D.S.; Tantapakul, C.; Maneerat, W.; Matainaho, T.; Julien, E.; Andersen, R. J. "Structures of Nahuoic Acids B to E Produced in Culture by a Streptomyces sp. Isolated from a Marine Sediment and Evidence for the Inhibition of the Histone Methyl Transferase SETD8 in Human Cancer Cells by Nahuoic Acid A". Journal of Organic Chemistry. 2016, 81 (4), 1324–133.  Featured Article. DOI 10.1021/acs.joc.5b02569
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33. Dalisay, D.S.; Kim, K.W.; Lee, C.; Yang, H.; Rübel, O.; Bowen, B.P.; Davin, L.B.;  Lewis, N.G. Dirigent-Protein-Mediated Lignan and Cyanogenic Glucoside Formation in Flax Seed: Integrated Omics and MALDI Mass Spectrometry Imaging.              
​Journal of Natural Products, 2015,  
26, 78(6), 1231-42.  DOI: 10.1021/acs.jnatprod.5b00023 
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ACS Editors' Choice Article.

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32. Monreal I.A., Liu, Q., Tyson, K., Bland, T., Dalisay. D.S., Adams, E.V., Wayman, G.A., Aguilar, H.C. and Saludes, J.P. Branched dimerization of Tat peptide improves permeability to HeLa and hippocampal neuronal cells. Chemical Communications (Cambridge). 2015, 51, 5463-5466. DOI: 10.1039/C5CC00882D.

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31. Seneviratne, H.R., Dalisay, D.S., Kim, K.W., Moinuddin, S.G.A., Yang, H., Hartshorn, C.M., Davin, L.B. and Lewis, N.G. Non-host disease resistance response in pea (Pisium sativum) pods: Biochemical function of DRR-206 and phytoalexin pathway localization. Phytochemistry, 2015, 113, 140–148. http://dx.doi.org/10.1016/j.phytochem.2014.10.013.



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30.  Marques, J.V., Dalisay, D.S., Yang, H., Lee, C., Davin, L.B. and Lewis NG. A multi-omics strategy resolves the elusive nature of alkaloids in Podophyllum species. Molecular BioSystems. 2014, 10, 2838-2849. DOI: 10.1039/c4mb00403e. Cover Feature. 
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29.  Ratnaweera, P., Williams, D.E., de Silva, E. D., Wijesundera, R., Dalisay, D.S and Andersen, R.J. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka.  Mycology 2014, 5, 23-28. DOI: 10.1080/21501203.2014.892905 
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28.  Costa, M.A., Marques, J.V., Dalisay, D.S., Herman, B., Bedgar, D.L., Davin, L.B. and Lewis N.G. Transgenic hybrid poplar for sustainable and scalable production of the commodity/specialty chemical, 2-phenylethanol. PLoS One, 2013 Dec 26;8(12):e83169. 
DOI: 10.1371/journal.pone.0083169. 
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27. Dalisay, D.S., Williams, D.E., Wang, X. L., Centko, R., Chen, J., and Andersen, R. J. Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural products. PLoS One, 2013 8:e77078 DOI: 10.1371/journal.pone.0077078
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26. Du, Y.L., Dalisay, D.S., Andersen, R. J., and Ryan, K. S. N-Carbamoylation of 2,4-diaminobutyrate reroutes the outcome in padanamide biosynthesis. Chemistry and Biology, 2013, 20, 1002-11. Cover Feature.  DOI:10.1016/j.chembiol.2013.06.013
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25.  Williams, D.E., Dalisay, D.S., Li, F., Amphlett, J., Maneerat, W., et al. Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM- competitive inhibitor of the histone methyltransferase SETD8. Organic Letters, 2012, 15, 414-417. DOI: 10.1021/ol303416k.
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24. Noro, J.C., Kalaitzis, J.A., Williams, D.E., Dalisay, D.S., Andersen, R.J., and Neilan, B.A. Tyrocidine a from a haliclona sponge derived Vibrio sp. Planta Medica, 2012, 78, 1161. DOI: 10.1055/s-0032-1320761.

23. Williams, D.E., Dalisay, D.S., Patrick, B.O., Matainaho, T., Andrusiak, K., Deshpande, R., Myers, C.L., Piotrowski, J.S., Boone, C., Yoshida, M., Andersen, R. J. “Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.” Organic Letters, 2011, 13, 3936-9. DOI: 10.1021/ol2014494.
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22. Dalisay, D.S., Saludes, J.P., Molinski, T.F. Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans. Bioorganic and Medicinal Chemistry. 2011,19, 6654-6657. DOI: 10.1016/j.bmc.2011.05.041.
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21. Pimenta, E. F., Vita-Marques, A. M., Tininis, A., Seleghim, M. H., Sette, L. D., Veloso, K., Ferreira, A. G., Williams, D. E., Patrick, B. O., Dalisay, D. S., Andersen, R. J., Berlinck, R. G. “Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species.” Journal of Natural Products. 2010, 73, 11:1821- 32. DOI: 10.1021/np100470h
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20.  Dalisay, D. S., Quach T, Molinski T. F. “Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association”. Organic Letters, 2010, 12, 7:1524-7. DOI: 10.1021/ol100249v.
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19. Rogers, E. W., Dalisay, D. S., Molinski, T F. “Zwittermicin A: synthesis of analogs and structure- activity studies.” Bioorganic and Medicinal Chemistry Letters, 2010, 20, 7:2183- 5. DOI: 10.1016/j.bmcl.2010.02.032.
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18. Dalisay, D. S., Molinski, T. F. “Structure elucidation at the nanomole scale. 3. Phorbasides G from Phorbas sp.” Journal of Natural Products, 2010, 73, 4:679-82. DOI: 10.1021/np1000297
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17. Skepper, C. K., Dalisay, D. S., Molinski, T. F. “Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.” Bioorganic and Medicinal Chemistry Letters, 2010, 20, 6:2029-32. 
DOI: 10.1016/j.bmcl.2010.01.068.
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16. Makarieva, T. N., Zakharenko, A. M., Dmitrenok, P. S., Guzii, A. G., Denisenko, V. A., Savina, A. S., Dalisay, D. S., Molinski,T. F., Stonik, V. A. “Isorhizochalin: a minor unprecedented bipolar sphingolipid of stereodivergent biogenesis from the Rhizochalina incrustata.” Lipids, 2009, 44, 12:1155-62.  DOI: 10.1007/s11745-009-3360-0.
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15. Smith, A. B. III, Liu Z, Hogan A. M., Dalisay, D. S., Molinski, T. F. ”Hemi-phorboxazole A: structure confirmation, analogue design and biological evaluation.” Organic Letters, 2009, 11, 16:3766-9. DOI: 10.1021/ol9014317.
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14.  Dalisay, D. S., Morinaka, B. I., Skepper, C. K., Molinski, T. F. “A tetrachloro polyketide hexahydro-1H-isoindolone, muironolide A, from the marine sponge Phorbas sp. natural products at the nanomole scale.” Journal of the American Chemical Society, 2009, 131, 22:7552-3.  DOI: 10.1021/ja9024929
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13. Dalisay, D. S., Quach, T, Nicholas, G. N., Molinski, T. F. “Amplification of the Cotton effect of a single chromophore through liposomal ordering-stereochemical assignment of plakinic acids I and J.” Angewandte Chemie International Edition Engl. 2009, 48, 24:4367-71. DOI: 10.1002/anie.200900888.
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12. Mulder, R. J., Shafer, C. M., Dalisay, D. S., Molinski, T. F. “Synthesis and structure- activity relationships of bengazole A analogs.” Bioorganic and Medicinal Chemistry Letters, 2009, 19,11:2928-30. DOI: 10.1016/j.bmcl.2009.04.069.
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11. Dalisay, D. S., Molinski, T. F. Structure elucidation at the nanomole-scale. 2. Hemiphorboxazole A from Phorbas sp. Organic Letters, 2009, 11, 1967-70. DOI: 10.1021/ol9004189.
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10.  Dalisay, D. S., Molinski, T. F. NMR quantitation of natural products at the nano-mole scale. Journal of Natural Products. 2009, 72, 739-44. DOI: 10.1021/np900009b
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9. Dalisay, D. S., Rogers, E. W., Edison, A. S., Molinski, T. F. Structure elucidation at the nanomole-scale. 1. Trisoxazole macrolides and thiazole-containing cyclic peptides from the nudibranch Hexabranchus sanguineus. Journal of Natural Products, 2009, 72, 732-38. DOI: 10.1021/np8007649.
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8. Dalisay, D. S., Tsukamoto, S. Molinski, T. F. Absolute Configuration of the bifunctionalized sphingolipid leucettamol A from Leucetta microrhaphis by deconvoluted exciton coupled CD. Journal of Natural Products, 2009, 72, 353-359. DOI: 10.1021/np800549n.
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7.  Molinski, T. F., Dalisay, D. S., Lievens, S. L., Saludes, J. P. Drug development from marine natural products. Nature Reviews Drug Discovery. 2009, 8, 69-85. Cover Feature. DOI:10.1038/nrd2487 
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6.  Skepper, C.K., Dalisay, D. S., Molinski, T. F. Synthesis and antifungal activity of (-)-(Z)- dysidazirine. Organic Letters. 2008, 10, 5269-71. DOI: 10.1021/ol802065d. 
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5.  Molinski, T. F., Dalisay, D. S., Morinaka, B. I., Quach, T. Configuration of natural products: Liposomal circular dichroism (LCD) for acyclic stereocenters. Planta Medica, 2008, 74, 923-924. DOI: 10.1055/s-0028-1083949
4.  Thomas, T., Evans, F. F., Schleheck, D., Mai-Prochnow, A., Burke, C., Penesyan, A., Dalisay, D. S., Stelzer-Braid, S., Saunders, N., Johnson, J., Ferriera, S., Kjelleberg, S., Egan, S. Analysis of the Pseudoalteromonas tunicata genome reveals properties of a surface-associated life style in the marine environment. PLoS ONE, 2008, 3(9):e3252 DOI:10.1371/journal.pone.0003252. 
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3. Rogers, E. W., Dalisay, D. S., Molinski, T. F. (+)-Zwittermicin A: assignment of its complete configuration by total synthesis of the enantiomer and implication of D-serine in its biosynthesis. Angewandte Chemie International Edition Engl. 2008, 47, 8086-9. 
DOI: 10.1002/anie.200801561
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2. Dalisay, D. S, Webb, J. W., Scheffel, A., Svenson, C., James, S., Holmström, C., Egan, S. and S. Kjelleberg. A mannose-sensitive haemagglutinin (MSHA)-like pilus promotes attachment of Pseudoalteromonas tunicata cells to the surface of the green alga Ulva australis. Microbiology, 2006,152, 2875-2883. DOI: 10.1099/mic.0.29158-0
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1.  Mai-Prochnow, A., Evans, F., Dalisay-Saludes, D.S., Stelzer, S., Egan, S., James, S., Webb, J. S. and S. Kjelleberg. Biofilm development and cell death in the inhibitory marine bacterium Pseudoalteromonas tunicata. Applied and Environmental Microbiology, 2004, 70, 3232-8. DOI: 10.1128/AEM.70.6.3232-3238.2004
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